METHOD FOR PRODUCING A tubular article anti-microbial, METHOD FOR PRODUCING antimicrobial coating on polyurethane catheters, mainly multi-channel and multi-channel catheter with antimicrobial coating

摘要

1. A method of making tubular articles from polyurethane with an antimicrobial coating, which consists in obtaining the tubular article by extrusion using a screw extruder of the required diameter of the tube, followed by cutting it into desired lengths with a further modification of the surface of tubular articles with chlorhexidine and / or salts thereof, wherein that modification is carried out in three stages, comprising: - impregnating the articles with chlorhexidine surface and / or its salts by treatment with the product during 14-180 min bottom-alcoholic solutions of chlorhexidine and / or its salts at a temperature of 20-60 ° C with the following ratio of ingredients, wt. %: - removing excess chlorhexidine and / or its salts from the surface of the impregnated article; - the subsequent application of 0.5-4% polyurethane solution with a molecular weight of from 10,000 to 40,000 units. in tetrahydrofuran containing hlorgesidin and / or its salt in an amount of 0.25-5% (wt.) relative to the mass of polyurethane, and evaporation tetragidrofurana.2. A method according to claim 1, characterized in that the chlorhexidine salts are used as the dihydrochloride or the diacetate or biglyukonat.3. A method according to claim 1, characterized in that the removal of excess chlorhexidine and / or its salts from the surface of the impregnated products produced by wiping surfaces impregnated catheters damp cotton or viscose tissue with 50-60% humidity at room temperature, followed by wiping to remove excess moisture dry cotton or viscose tkanyu.4. A method for producing an antimicrobial coating on tubular articles of polyurethane, preferably multichannel, Modifying the