ANTIBODIES TO INTERLEUKIN-1α, AND ITS APPLICATION METHODS

摘要

FIELD: biotechnologies.;SUBSTANCE: antibody includes a heavy chain covalently connected to a light chain, for which amino-acid sequences have been determined. Antigen-binding variable region demonstrates very high affineness of binding with IL-1α, and contact region is effective both in activation of the complement system by means of C1q binding, and in binding with several different Fc-receptors. Also, a set of allocated nucleic acids (NA) is described, which contains the first NA coding the heavy chain of human IgG mab, and the second NA coding the light chain IgG mab. A set of allocated NA can be contained in the expressing vector or the host cell, in particular, a cell of a mammal, which expresses light and heavy chains of the antibody.;EFFECT: use of the invention allows successful application of such Abs for therapy, prevention or detection of a pathology associated with aberrant expression IL-1α.;7 cl, 13 ex