NOVEL SINGLE-UNIT FORMULATIONS OF CARBAPENEM AND AMINOGLYCOSIDE

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: invention refers to pharmaceutical formulations and is applicable for providing bactericidal efficacy. A pharmaceutical formulation contains two various antibiotics as active ingredients in the form of a synergetic combination of a fixed dose in a parenteral dosage form. The first antibiotic represents carbapenem or its pharmaceutically acceptable salts, while the second antibiotic represents aminoglycoside which represents etimycin or its pharmaceutically acceptable salts. The above first antibiotic and the above second antibiotic are found in weight ratio of 6:1 to 13:1. Besides, the pharmaceutical formulation contains one or more additives specified from a group of synthetic/natural amino acids/vitamins/stabilisers/polymers/antioxidants/micronutrient elements.;EFFECT: pharmaceutical formulation used in the very low concentrations, provides higher clinical effectiveness in the patients suffering from or sensitive to mixed multibacterial lethal infections, with a low tolerance to drugs and disease, and having a risk of potential toxicity, wherein potential toxicity caused by high doses provides a cause for concern.;8 cl, 3 tbl, 6 dwg, 1 ex