NOVEL SINGLE UNIT CARBAPENEM AMINOGLYCOSIDE FORMULATIONS THE AMINOGLYCOSIDE IS ETIMICIN

摘要

Disclosed is a pharmaceutical formulation for reduction in drug and disease induced toxicities achieved by reducing dose, said pharmaceutical formulation comprising: two different group of antibiotics as active constituents present as synergistic fixed dose combination in parenteral dosage form with bactericidal efficacy, wherein a first antibiotic is a carbapenem or a pharmaceutically acceptable salts thereof; wherein a second antibiotic is an aminoglycoside which is etimicin or a pharmaceutically acceptable salts thereof; and wherein said first antibiotic and said second antibiotics are present in weight ratios of 6:1 to 13:1; wherein said pharmaceutical formulation comprises one or more of additive selected from a group of synthetic/ natural amino acids/ vitamins/ stabilizers/ polymers/ antioxidants/ micronutrients. The composition preferably also includes EDTA.