METHOD FOR PREVENTING AND TREATING GASTRIC ULCER LESION CAUSED BY ADMINISTERING NONSTEROIDAL ANTIINFLAMMATORY AGENTS

摘要

FIELD: medicine.;SUBSTANCE: preventive agent is presented by one of phenylthioacetamide derivatives of the general formula: wherein R¹=H, Me; R²=H; R³=CH₂COOMe, CH(Me)COOMe, CH(Et)COOMe, CH(CH₂CH₂SMe)COOMe, CH₂COOH, CH(Me)COOH, CH(Et)COOH, CH(CH₂CH₂SMe)COOH, CH₂CH₂CH₂CH₂CH(NH₂)COOH, CH₂CH₂CH₂CH(NH₂)COOH; R², R³=CH₂CH₂CH₂CH(COOMe); R², R³=CH₂CH₂CH₂CH(COOH). The above compounds are administered parenterally in a dose of 0.5-90 mg/kg, particularly in a dose of 1-3 mg/kg 10-120 minutes before administering nonsteroidal anti-inflammatory agents (e.g. aspirin or indomethacin), particularly 30 minutes before administering the nonsteroidal anti-inflammatory agents (e.g. aspirin or indomethacin) that enables reducing an area of erosions and ulcers of the gastric mucosa by 2-4 times as compared to a reference group receiving the nonsteroidal anti-inflammatory agents and receiving no declared compounds. The above phenylthioacetamides are applicable for preventing and treating the gastric ulcer caused by administering the therapeutic agents containing the nonsteroidal anti-inflammatory preparations of salycylates and acetic acid derivatives. The areas of the ulcer formation caused by the action of the nonsteroidal anti-inflammatory agents of salycylates (e.g. aspirin-containing) and acetic acid derivatives (e.g. indomethacin-containing) decrease after administering the phenylthioacetamide derivatives in the mammalian gastric mucosa.;EFFECT: higher clinical effectiveness.;6 cl, 12 ex, 9 dwg