Mesoporous silica particles and their use in drug delivery

摘要

A substantially monodisperse assemblage of particles 10 having interconnected nanopores 20 and a core 30 with a shell 40 disposed about the core 30 wherein the particles 10 have a cubic crystal form. In another aspect, a method for the sustained release of an active substance to an environment comprising adding an active substance to the particles 10, placing restrictions 50 in the interconnected nanopores 20 within the shell 40 by covalent bonding (preferably using dextran polymers) and placing the particles with the added active substance in the environment. The particles are preferably either nanoprous or mesoporous silica. Alternatively, a method for the manufacture of a plurality of monodisperse particles 10 comprising: mixing an ionic surfactant (preferably cetyltriethylammonium bromide) with an inorganic salt (preferably sodium sulfate) in hydrochloric acid; mixing a co-solvent with a nonionic surfactant (preferably a polyalkylene oxide) and an oxide source (preferably TEOS); and mixing the two together.