Fabrication of Stable Bio-Compatible Mesoporous Silica and Core-Shell Silica-Magnetite Nanoparticles for Potential Application In Drug Delivery

摘要

Herein, we report the fabrication and characterization of stable bio-compatible core-shell superparamagnetic iron oxide nanoparticles (SPIONs) of ～60 nm to 80 diameters and their in vitro drug loading / releasing study of anticancer drug Mitomycin C. This study consists of two different coatings on SPIONs, mesoporous silica shell and lipid bilayer shell. The in vitro drug loading and releasing studies were carried in phosphate buffer solution and determined by UV-Visible spectrophotometer and the stability study of bio-compatible core-shell nanoparticles in suspension were determined by magnetic susceptibility measurement and magnetic sedimentation study using scanning column magnetometry (SCM). The mesoporosity of the silica shell and the diameter of the particles were determined by small angle X-ray scattering (SAXS) and transmission electron microscope (TEM).