P-TOLUENESULFONIC ACID SALT(CM4307.TsOH) OF 4-(4-(3-(4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)UREIDO)-PHENOXY)-N-(1',1',1'-TRIDEUTEROMETHYL)PICOLINAMIDE, METHOD OF PRODUCING CM4307.TsOH AND MEDICAL COMPOSITION CONTAINING CM4307.TsOH

摘要

PROBLEM TO BE SOLVED: To provide a novel compound having a chemical pharmacological function higher than the inhibitory activity of raf kinase and its application.SOLUTION: Deuterated -diphenylurea of the following formula and its production method are provided. In an application method, deuterated -diphenylurea, or N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-1',1',1'-trideuteromethylaminoformyl)-4-pyridyloxy)phenyl) urea, capable of inhibiting phosphoric acid kinase is used in therapy and prevention of tumor and related diseases.