MODIFICATION OF AMYLOID- LOAD IN NON-BRAIN TISSUE

摘要

PROBLEM TO BE SOLVED: To provide methods and compositions for modulating levels of amyloid- peptide (A) exhibited by non-neuronal (i.e., peripheral) cells, fluids, or tissues, and to provide a modulation method of A levels via selective modulation (e.g., inhibition) of -secretase activity.SOLUTION: The invention relates to methods of preventing, treating or ameliorating the symptoms of a disorder, including but not limited to an A-related disorder, by administering imatinib or its pharmaceutically acceptable salt that results in the modulation of -secretase in a non-neuronal tissue, either directly or indirectly to prevent, treat or ameliorate the symptoms of a brain A disorder, such as Alzheimer's disease. This invention further relates to an effective amount of second therapeutic agent for treating the brain A disorder, such as cannabinoids, dimebon, prednisone, ibuprofen, naproxen, indomethacin, and statin.