首页>
外国专利>
MODIFICATION OF AMYLOID-BETA LOAD IN NON-BRAIN TISSUE.
MODIFICATION OF AMYLOID-BETA LOAD IN NON-BRAIN TISSUE.
展开▼
机译:非脑组织中淀粉样蛋白负荷的修改。
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to methods and compositions for modulating levels of amyloid-β peptide (Aβ) exhibited by non-neuronal (i.e., peripheral) cells, fluids, or tissues. The invention also relates to modulation of Aβ levels via selective modulation (e.g., inhibition) of γ-secretase activity. The invention also relates to methods of preventing, treating or ameliorating the symptoms of a disorder, including but not limited to an Aβ-related disorder, by administering a compound that result in the modulation of γ-secretase in a non-neuronal tissue, either directly or indirectly to prevent, treat or ameliorate the symptoms of a brain Aβ disorder, such as Alzheimer's disease.
展开▼