A composition comprising two antibodies engineered to have reduced and increased effector function.

摘要

The present invention relates to (a) a first antibody engineered to have reduced effector function, an immunoconjugate comprising an effector moiety, and (b) increased used in an individual in need thereof for treatment of a disease. A combination of second antibodies engineered to have a specific effector function. Further provided are pharmaceutical compositions comprising the combination and methods of using them.