Method for generating a pH / ion concentration gradient in the vicinity of an electrode surface to regulate biomolecular interactions

摘要

A method of modulating the binding interaction between a (biomolecule) probe or detection agent and a target analyte from a biological sample in a biosensor having a multi-site array of test sites. In particular, the method adjusts the pH or ion concentration gradient in the vicinity of the electrode in such a biosensor. Methods for modulating binding interactions provide biosensors and analytical methods for more accurately measuring analytes of interest in biological samples. [Selection figure] None