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Method and apparatus for producing a patient model of medullary meduloblastoma

机译:产生髓样成神经细胞瘤患者模型的方法和设备

摘要

The present invention comprises: (a) dividing the glioblastoma tissue separated from the patient into four or more compartments, collecting one or more sections in each compartment, and (b) separating the filamentous cells into a single cell (single cell) unit of separation of each of the collected sections C) a method for producing a glioblastoma mouse model including a process of transplanting a transplanted sample containing a glioblastoma cell separated in the above (b) into a brain of an immunodeficient mouse, and a mouse model of glioblastoma produced by the method, said mouse The present invention relates to a method of screening a glioblastoma therapeutic agent using a model, and an information providing method for selecting a method of treating a patient's order made type glioblastoma method using the mouse model. The mouse model of glioblastoma according to the present invention is useful for safe and effective selection of therapeutic methods for treating patients with medulloblastoma.
机译:本发明包括:(a)将与患者分离的胶质母细胞瘤组织分成四个或更多个隔室,在每个隔室中收集一个或多个切片,以及(b)将丝状细胞分离成单个细胞(单细胞)分离单元(C))制备胶质母细胞瘤小鼠模型的方法,该方法包括将包含上述(b)中分离的包含胶质母细胞瘤细胞的移植样品移植到免疫缺陷小鼠的大脑中的方法,以及制备的胶质母细胞瘤小鼠模型通过所述方法,所述小鼠本发明涉及使用模型筛选胶质母细胞瘤治疗剂的方法,以及选择使用所述小鼠模型治疗患者定型胶质母细胞瘤方法的信息提供方法。根据本发明的胶质母细胞瘤的小鼠模型可用于安全有效地选择治疗髓母细胞瘤患者的治疗方法。

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