TREATMENT OF EYE DISEASES AND EXCESSIVE NEOVASCULARIZATION USING COMBINED THERAPY

摘要

PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for treating or preventing eye diseases caused by excessive neovascularization by vascular endothelial growth factor (VEGF)-signaling.SOLUTION: The pharmaceutical composition is i) mesenchymal precursor cells, and ii) a compound that disrupts vascular endothelial growth factor (VEGF)-signaling, where the compound is either: a polypeptide which is an antibody, an antibody-related molecule, and/or a fragment of an antibody or an antibody-related molecule; or a polynucleotide which is, or encodes one or more of, an antisense polynucleotide, a sense polynucleotide, a catalytic polynucleotide, or a duplex RNA molecule.