NOVEL POLYMORPH OF 3-(1-{3-5-(1-METHYL-PIPERIDINE-4-YLMETHOXY)-PYRIMIDINE-2-YL-BENZYL}-6-OXO-1,6-DIHYDRO-PYRIDAZINE-3-YL)-BENZONITRILE HYDROCHLORIDE AND PRODUCTION METHOD THEREOF

摘要

PROBLEM TO BE SOLVED: To provide a novel form of a solvate of 3-(1-{3-[5-(1-methyl-piperidine-4-ylmethoxy)-pyrimidine-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazine-3-yl)-benzonitrile hydrochloride and its novel polymorphs.SOLUTION: A hydrochloride solvate of 3-(1-{3-[5-(1-methyl-piperidine-4-ylmethoxy)-pyrimidine-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazine-3-yl)-benzonitrile represented by formula (I), its crystal transformations and a method of producing the crystal transformations are provided.