cell models and animal models for screening a therapeutic agent for the treatment of Alzheimer's disease

摘要

In the present specification, construct for assaying for a candidate therapeutic agent for the treatment of Alzheimer's disease , model, and how I describe. In certain embodiments, (a) a chaperone protein or a monosaccharide transferase (MST) (b) a polynucleotide encoding a fusion protein of the fluorescent protein is included in the construct. In one embodiment, the fusion is at least one exon of a polynucleotide encoding a chaperone protein, or MST, occurs where followed by polynucleotide encoding a fluorescent protein.