How to convert the mesenchymal stem cells quickly to hematopoietic stem cells and induced to high purity in a large

摘要

The present invention is transformed into a step 1 for preparing a culture medium of homogeneous mesenchymal stem cells, a step 2 for combining various small RNA molecules, and a step 3 for assembling and transfecting nucleic acid and polypeptide nanoparticles. Inducing and proliferating hematopoietic stem cell culture medium and transforming the mesenchymal stem cells into hematopoietic stem cells rapidly and with high purity on a large scale, including step 4 for activating and proliferating various hematopoietic-related genes Provide a method. It is possible to solve the technical bottleneck problems that are difficult in cell matching for hematopoietic stem cell therapy, immune rejection and the number of hematopoietic stem cells are limited in the prior art. [Selection] Figure 1