PROBLEM TO BE SOLVED: To provide preparation particles composing a pseudoephedrine-mixed sustained release preparation which is dosed as a granule agent or a dispersing agent as it is, is provided as a capsule by encapsulating it in a gelatin hard capsule, has a suitable size without enlarging these preparations when mixed with other excipients, subjected to compression molding and made into a tablet, does not require considerable time in the production thereof, causes elution of pseudoephedrine or a salt thereof to be delayed when applied with film coating, and retains the drug effect of pseudoephedrine over a long period of time directly after dosing by combining with immediately release pseudoephedrine-containing preparation particles, for example preparation particles without being applied with film coating.;SOLUTION: The preparation particle does not include nuclear particles made of only an excipient, includes pseudoephedrine or a salt thereof and the excipient, has a mean particle diameter of 500 to 1,500 μm, has a geometric standard deviation of particle size distribution of 1.4 or less, and has spheroidicity of 0.7 or higher.;COPYRIGHT: (C)2011,JPO&INPIT
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