Methods and compositions relating to miR-21 and miR-29a, exosome inhibition, and cancer metastasis

摘要

The present invention shows that tumor-secreted miR-21 and miR-29a bind to mouse TLR7 and human TLR8, which are receptors of the Toll-like receptor family, as ligands in immune cells and are mediated by TLR-mediated proliferative inflammation It can function by inducing a response, which provides materials and methods related to the discovery that it leads to tumor growth and metastasis. Thus, secreted miRNAs by acting as TLR paracrine agonists are important regulators of the tumor microenvironment. The mechanism of action of this miRNA is important in tumor-immune system communication, in tumor growth and spread, and in cancer treatment. [Selection figure] None