首页>
外国专利>
Application of diindolylmethane and its precursors and their derivatives in the manufacture of drugs for the treatment of liver diseases
Application of diindolylmethane and its precursors and their derivatives in the manufacture of drugs for the treatment of liver diseases
展开▼
机译:二吲哚基甲烷及其前体及其衍生物在制备治疗肝病药物中的应用
展开▼
页面导航
摘要
著录项
相似文献
摘要
This invention relates to biopharmaceutical technology, specifically to the application of 3,3'-Diindolylmethane, indole-3-carbinol, and derivatives thereof in the preparation of drugs for treating such hepatic diseases as viral hepatitis, alcoholic hepatitis, drug-induced hepatitis, fatty liver, hepatic fibrosis and hepatic cirrhosis. The said indole-3-carbinol, diindolylmethane and derivatives thereof can effectively protect the human body from the damage resulting from ROS by inhibiting ROS-induced activation of hepatic stellate cells and correlated expression of collagen, which consequently ameliorates degree of hepatic fibrosis. Therefore they can be used in treatment of diseases related to hepatic fibrosis. As is verified in the animal models of hepatic fibrosis, the said indole-3-carbinol, diindolylmethane and derivatives thereof present excellent therapeutic effect and positive application prospect.
展开▼