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The novel insulin derivatives having an extremely time-action profile which is delayed
The novel insulin derivatives having an extremely time-action profile which is delayed
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机译:新型的胰岛素衍生物具有极大的时间作用特征,这种作用被延迟
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摘要
The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the addition and/or substitution of negatively and positively charged amino acid residues and by an amidation of the C-terminal carboxy group of the B chain and histidine in position 8 of the insulin A chain. The invention also relates to the production and use thereof.
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