1,2,4-triazole as allosteric modulators of mGlu5 receptor activity for the treatment of dementia of schizophrenia

摘要

The present invention relates to compounds of formula I, their use as positive allosteric modulators of ImGlu5 receptor activity, pharmaceutical compositions comprising them, and glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive dysfunction Relates to their use as medicaments for the treatment and / or prevention of neurological and psychiatric disorders associated with. A, B, X, R1, R2, R3 have the meanings given in the specification.