antigen-binding molecule that promotes the elimination from the blood plasma of antigen, including the sugar chain receptor binding domain

摘要

Include carbohydrate receptor binding domain, the antigen binding activity weaker antigen-binding molecule at pH in the early endosomes as compared to antigen-binding activity at pH in plasma, as well as pharmaceutical compositions comprising said antigen binding molecule, and their preparation methods are disclosed. The use of antigen-binding molecules of the invention, along with uptake into the cell of an antigen is promoted, it is possible to increase the number of antigen with which an antibody of the molecule can bind to the plasma by administration of an antibody as well as promoting the reduction antigens, it is possible to prolong the pharmacokinetics of the antibody.