An antigen-binding molecule that promotes elimination of an antigen containing a sugar chain receptor-binding domain from plasma

摘要

PROBLEM TO BE SOLVED: To promote the uptake of an antigen into cells and to increase the number of antigens to which one molecule of antibody can bind, and to administer the antibody to promote the decrease of antigen in plasma, Provided are an antigen-binding molecule, a pharmaceutical composition containing the antigen-binding molecule, and a method for producing them, which makes it possible to prolong the pharmacokinetics of an antibody. An antigen-binding molecule containing a sugar chain receptor-binding domain and having a weaker antigen-binding activity at pH in early endosomes than the antigen-binding activity at pH in plasma. [Selection diagram] None