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An antigen-binding molecule that promotes the elimination of an antigen containing a carbohydrate receptor-binding domain from plasma
An antigen-binding molecule that promotes the elimination of an antigen containing a carbohydrate receptor-binding domain from plasma
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机译:促进从血浆中消除含有糖类受体结合域的抗原的抗原结合分子
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摘要
Disclosed are an antigen-binding molecule containing a sugar chain receptor-binding domain and having a weak antigen-binding activity in the pH of early-stage endosome compared to the antigen-binding activity in the pH of plasma; a pharmaceutical composition containing the antigen-binding molecule; and a method for producing these. Use of the antigen-binding molecule of the invention enables to promote uptake of an antigen into a cell and increase the number of antigens that a single antibody molecule can bind. Administration of the antibody enables to reduce the number of antigens in plasma more and more and improve pharmacokinetics of the antibody.
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