Methylglyoxal such accumulation method, methylglyoxal such measurement method, methylglyoxal such accumulation model animal and a method of manufacturing the same, and screening methods

摘要

Challenge Normal laboratory animals by measuring methylglyoxal about Sar such accumulation of methylglyoxal such accumulation model animal that was produced was treated by a method of performing reperfusion after cerebral ischemia or cerebral ischemia, appropriately methylglyoxal such related diseases and simple win to provide an evaluation model of evaluation to be methylglyoxal such accumulation in a short period of time to. A The present invention consists of a method for accumulating the methylglyoxal acids by normal experimental animal was treated by the method of performing reperfusion after cerebral ischemia or cerebral ischemia. The present invention also normal experimental animals were treated by a method of performing reperfusion after cerebral ischemia or cerebral ischemia was produced methylglyoxal such animal model by measuring the accumulation degree of the methylglyoxal include methyl glyoxal and it consists examining the class-related diseases. Furthermore, the present invention is a candidate agent is also useful in screening methods for examining whether have efficacy in a disease thought to be involved in MGO like. .BACKGROUND