ERAP1-derived peptides and uses thereof

摘要

A novel cancer therapeutic agent that can be a new option for cancer treatment is provided. Specifically, the present invention provides a peptide that contains a binding site for the PHB2 polypeptide in the ERAP1 polypeptide and inhibits the binding between the ERAP1 polypeptide and the PHB2 polypeptide, and a pharmaceutical composition containing the peptide. Also provided is a method for screening drug candidates for treating and / or preventing cancer using inhibition of binding between ERAP1 polypeptide and PP1α polypeptide, PKA polypeptide or PKB polypeptide as an index.