METHODS AND COMPOSITIONS FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR-1alpha (PGC1alpha) AS A TARGET OF CIRCULATING TUMOR CELLS

摘要

The present invention relates to methods, compositions, and diagnostic tests for treating and diagnosing a metastatic as disease that results in increased mitochondrial respiration and/or biogenesis. In particular, the methods and compositions include treatment of metastatic diseases such as breast cancer using an antagonist of mitochondrial respiration such as a PGC1α antagonist.