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Leukemic cell CNS infiltration controlled by notch-induced chemotaxis

机译：Notch诱导的趋化性控制白血病细胞CNS的浸润

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摘要

The present invention is directed to methods of preventing central nervous system leukemia, treating T-cell acute lymphoblastic leukemia, and treating immune system disorders associated with CCR7-CCL19 mediated signaling. Suitable therapeutic agents for inhibiting CCR7-CCL19 signaling and methods of identifying additional therapeutic agents useful in the methods of the present invention are also disclosed.

机译：本发明涉及预防中枢神经系统白血病，治疗T细胞急性淋巴细胞白血病以及治疗与CCR7-CCL19介导的信号传导相关的免疫系统疾病的方法。还公开了用于抑制CCR7-CCL19信号传导的合适的治疗剂以及鉴定可用于本发明方法的其他治疗剂的方法。

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公开/公告号US9101559B2

专利类型
公开/公告日2015-08-11

原文格式PDF
申请/专利权人 IANNIS AIFANTIS;SILVIA BUONAMICI;
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申请/专利号US20100776920
发明设计人 IANNIS AIFANTIS;SILVIA BUONAMICI;
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申请日2010-05-10
分类号A61K38/02;A61K31;A61K31/439;A61K31/519;A61K31/704;G01N33/50;A61K31/573;A61K31/7068;A61K31/7088;A61K38/50;A61K45/06;G01N33/574;
国家 US
入库时间 2022-08-21 15:23:47

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