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Methods for the Detection of Advanced Glycation Endproducts and Markers for Disease

机译:检测高级糖基化终产物和疾病标志物的方法

摘要

The present invention provides compositions and methods for detecting carboxymethyl-lysine (CML) and circulating receptor for advanced glycation end (RAGE) products, and methods for correlating CML and RAGE levels with age-related disease. In particular, serum CML and/or circulating receptor for advanced glycation end (RAGE) products can be used as a clinical biomarker in diagnostics to identify people who are at a higher risk of developing adverse ageing-related outcomes.
机译:本发明提供了用于检测羧甲基赖氨酸(CML)和晚期糖基化末端(RAGE)产物的循环受体的组合物和方法,以及使CML和RAGE水平与年龄相关疾病相关的方法。尤其是,晚期糖基化终末期(RAGE)产品的血清CML和/或循环受体可以用作诊断中的临床生物标志物,以识别出出现不良衰老相关结果的风险较高的人群。

著录项

  • 公开/公告号US2015051161A1

    专利类型

  • 公开/公告日2015-02-19

    原文格式PDF

  • 申请/专利权人 THE JOHNS HOPKINS UNIVERSITY;

    申请/专利号US201414249451

  • 申请日2014-04-10

  • 分类号G01N33/53;A61K31/426;A61K31/60;A61K31/40;A61K31/498;A61K31/496;A61K31/155;A61K38/05;

  • 国家 US

  • 入库时间 2022-08-21 15:23:42

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