AL-F-18-LABELED, AL-F-19-LABELED AND GA-68-LABELED GASTRIN-RELEASING PEPTIDE RECEPTOR (GRPR)-ANTAGONISTS FOR IMAGING OF PROSTATE CANCER

摘要

The present application discloses compositions and methods of synthesis and use of ¹⁸F-, ¹⁹F- or ⁶⁸Ga-labeled molecules of use in PET, SPECT and/or MRI imaging of prostate cancer. Preferably, the ¹⁸F, ¹⁹F or ⁶⁸Ga is attached to a chelator moiety on a prostate cancer targeting molecule, more preferably a bombesin analog, more preferably a GRPR antagonist, most preferably JMV5132 or JMV4168. The ¹⁸F or ¹⁹F may form a complex with a group IIIA metal to promote binding to the chelators. The labeled molecules may be used to detect, diagnose and/or image prostate cancer, including metastatic prostate cancer, in vivo.