Pimecrolimus foam composition containing hexylene glycol, optionally oleyl alcohol, dimethylisosorbide and/or medium chain triglycerides

摘要

Pharmaceutical foam compositions substantially free of ethanol and comprising pimecrolimus in a carrier vehicle comprising a mixture of oily solvents amounting to at least 40% of the total weight of the composition and consisting of:i) hexylene glycol;ii) optionally oleyl alcohol; andiii) dimethylisosorbide and/or medium chain triglycerides;and additionally:iv) when oleyl alcohol is absent, water in an amount of less than 25%;v) at least one consistency agent;vi) at least one preservative; andvii) at least one surfactant/emulgator; and propellant gas for foaming;and optionally further conventional excipients.;They are indicated for use in the treatment of various skin, nail and mucosal diseases.