Electrokinetic microfluidic flow cytometer apparatuses with differential resistive particle counting and optical sorting

摘要

The present invention provides electrokinetic microfluidic cytometers useful for detecting and/or sorting fluid-borne particles. In some embodiments, the electrokinetic microfluidic flow cytometer apparatus comprises a substrate having a microchannel formed therein, a particle-sensing gate that reduces the cross-sectional area of a portion of the microchannel, a pair of signal- and noise-detection electrodes, and a particle-detection circuit that is electrically connected to the signal- and noise-detection electrodes and is configured to generate a particle-detection signal responsive to differences in resistivity across the particle-sensing gate.