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Chemo- and radiation-sensitization of cancer by antisense TRPM-2 oligodeoxynucleotides
Chemo- and radiation-sensitization of cancer by antisense TRPM-2 oligodeoxynucleotides
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机译:反义TRPM-2寡脱氧核苷酸对癌症的化学和放射致敏作用
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摘要
Administration of antisense oligodeoxynucleotides (ODN) targeted against the testosterone-repressed prostate message-2 (TRPM-2) gene can reduce the amount of TRPM-2 in renal cell cancer (RCC) cells and other cancer cells, and as a result enhance chemosensitivity of these cells to chemotherapy agents and radiation. Thus, for example, the sensitivity of renal cell cancer cells to a chemotherapeutic agent can be increased by exposing renal cell cancer cells to a chemotherapeutic agent and an agent which reduces the amount of TRPM-2 in the renal cell cancer cells. This provides an improved method for treatment of renal cell cancer, which is generally resistant to treatment with known chemotherapy agents.
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