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Generating epigenetic cohorts through clustering of epigenetic surprisal data based on parameters

机译:通过基于参数的表观遗传数据的聚类生成表观队列

摘要

A method, computer program product, and system generating epigenetic cohorts for a specific time period through clustering of epigenetic surprisal data at a specific time comprising. receiving a phenotypic and/or demographic parameter and a cluster characteristics input from a user; searching the epigenetic surprisal data at a specific time for the parameter and storing matches in a repository; generating a cluster comprising a centroid for each parameter by populating the cluster based on the matches of the parameter with the epigenetic surprisal data at a specific time period; determining at least two epigenetic cohorts for a specific time period from the cluster for each parameter and based on the input from the user; and if the cohorts do not match the input of the user, reporting the cohorts determined to the user and returning to the step of receiving a parameter and characteristic input from a user.
机译:一种通过在特定时间对表观遗传数据进行聚类来生成特定时间段的表观遗传队列的方法,计算机程序产品和系统。接收来自用户的表型和/或人口统计学参数和聚类特征输入;在特定时间搜索表观遗传数据以查找参数并将匹配项存储在存储库中;通过在特定时间段基于参数与表观遗传数据的匹配填充聚类来生成包括每个参数的质心的聚类;根据用户的输入,从聚类中为每个参数确定特定时间段内的至少两个表观遗传队列;如果同类群组与用户的输入不匹配,则向用户报告确定的同类群组,并返回至接收来自用户的参数和特征输入的步骤。

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