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Nucleic acid aptamers against plasmodium lactate dehydrogenase and histidine-rich protein II and uses thereof for malaria diagnosis

机译：抗乳酸疟原虫脱氢酶和富含组氨酸蛋白II的核酸适体及其在疟疾诊断中的用途

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摘要

The present invention provides nucleic acid aptamers that bind to Plasmodium proteins lactate dehydrogenase and histidine-rich protein II, and uses thereof for the diagnosis of malaria. Aptamers against histidine-rich protein II may be used to detect the presence of Plasmodium species in general, whereas aptamers against lactate dehydrogenase can be used to specifically detect Plasmodium falciparum.

机译：本发明提供了与疟原虫蛋白乳酸脱氢酶和富含组氨酸的蛋白II结合的核酸适体，及其在疟疾诊断中的用途。一般而言，针对富含组氨酸的蛋白质II的适体可用于检测疟原虫的种类，而针对乳酸脱氢酶的适体可用于特异性检测恶性疟原虫。 展开▼

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公开/公告号US9000137B2

专利类型

公开/公告日2015-04-07

原文格式PDF

申请/专利权人 THE UNIVERSITY OF HONG KONG;
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申请/专利号US201313763051

发明设计人 JULIAN A TANNER;YEE WAI CHEUNG;MASAYO KOTAKA;
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申请日2013-02-08

分类号C07H21/04;C12Q1/68;G01N33/53;G01N33/569;

国家 US

入库时间 2022-08-21 15:17:06

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1. 针对疟原虫乳酸脱氢酶和富含组氨酸蛋白II的核酸适体及其用于疟疾诊断的用途 [P] . 中国专利： CN104245957B . 2016.12.14

2. 针对疟原虫乳酸脱氢酶和富含组氨酸蛋白II的核酸适体及其用于疟疾诊断的用途 [P] . 中国专利： CN104245957A . 2014-12-24

3. NUCLEIC ACID APTAMERS AGAINST PLASMODIUM LACTATE DEHYDROGENASE AND HISTIDINE-RICH PROTEIN II AND USES THEREOF FOR MALARIA DIAGNOSIS [P] . 欧洲知识产权局专利： EP2812453B1 . 2017-09-27

机译：乳酸疟原虫脱氢酶和富含组氨酸蛋白II的核酸适体及其用于疟疾诊断的研究

4. NUCLEIC ACID APTAMERS AGAINST PLASMODIUM LACTATE DEHYDROGENASE AND HISTIDINE-RICH PROTEIN II AND USES THEREOF FOR MALARIA DIAGNOSIS [P] . 欧洲知识产权局专利： EP2812453A4 . 2015-12-16

机译：乳酸疟原虫脱氢酶和富含组氨酸蛋白II的核酸适体及其用于疟疾诊断的研究

5. NUCLEIC ACID APTAMERS AGAINST PLASMODIUM LACTATE DEHYDROGENASE AND HISTIDINE-RICH PROTEIN II AND USES THEREOF FOR MALARIA DIAGNOSIS [P] . 欧洲知识产权局专利： EP2812453A1 . 2014-12-17

机译：乳酸疟原虫脱氢酶和富含组氨酸蛋白II的核酸适体及其用于疟疾诊断的研究

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