Procedure for the synthesis of 3 - (2 - bromo - 4.5 - dimetoxifenil) propanenitrile, and application to the synthesis of Ivabradine and its Addition salts with a pharmaceutically acceptable acid

摘要

Claim 1: procedure for Synthesis of the compound of formula (1) wherein the compound of formula (2) is subjected to the action of n-bromosuccinimide in the presence of an organic solvent for the compound of formula (1).Claim 5: procedure according to claim 1, wherein the compound of formula (2) is prepared from the compound of formula (3) is transformed into a compound of formula (4) in the presence of a Phosphorus ylide and a base in an organic solvent.That transforms into a compound of formula (2) by a reduction reaction in the presence of a HYDRIDE Donor Agent in an organic Solvent or a mixture of Organic Solvents.