Multiepu00edtopo recombinant protein, its production process and its applications related to rubella

摘要

Multiepitopo recombinant protein, its production process and its applications related to measles. This invention relates to a recombinant antigenic protein, especially engenheirada biotechnologically, containing different viral epitopes or regions more prevalent of rubella virus for the most representative in Brazil and in the world.This is a protein multiepitopo containing flexible connectors with sizes suitable to facilitate the connection between the different epitopes or viral fragments. This structural feature gives the protein increased sensitivity and specificity in the recognition of antibodies to RV.In addition, the protein multiepitopo induces an immune response more wide, desirable for the care of different applications related to detection, immunization, prevention and treatment of rubella; which makes it useful in the preparation of different products of interest to industries Pharmaceutical and biotechnology.Such as diagnostic kits for the detection of rubella u00ed n vitro from samples of human physiological and imunogu00eanicas, compositions, vaccines, drugs and biopharmaceuticals for preventing and treating this disease. Additionally, as a raw material for the production of antibodies monoclo IC.Another aspect of the present invention is related to the process of obtaining this protein, based on the cloning and expression heteru00e1loga in microorganisms.