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Multiepu00edtopo recombinant protein, its production process and its applications related to cytomegalovirus

机译:Multiepedtopo重组蛋白,生产工艺及其在巨细胞病毒中的应用

摘要

1 / 1 Summary multiepu00edtopo recombinant protein, its production process and its applications related to cytomegalovirus, the present invention relates to a recombinant protein multiepu00edtopo containing dominant epitopes of structural proteins of cytomegalovirus, conserved between The different genotypes of CMV circulating in Brazil and in the world.Which have the potential to recognize both the acute phase (IgG) and chronic (IgM) of the disease. The epitopes are connected by flexible connectors peptides, minimizing steric impediment of the protein in solution.This protein is antigenic activity, and is used as an input for diagnostic kits of standardized in vitro, high sensitivity, for cytomegalovirus, from human physiological samples to identify individuals who have had contact with the CMV infection present U passed).
机译:1 / / 1总结多表位重组蛋白,其生产方法及其与巨细胞病毒有关的应用技术领域本发明涉及一种重组蛋白多表位,其包含巨细胞病毒结构蛋白的显性表位,在不同基因型的CMV之间保守。在巴西乃至全世界范围内,都有潜力识别该疾病的急性期(IgG)和慢性期(IgM)。这些表位通过柔性连接器肽连接,从而最大程度地减少了溶液中蛋白质的空间障碍,该蛋白质具有抗原活性,可作为标准的体外诊断试剂盒的输入,用于高灵敏度,巨细胞病毒的诊断试剂盒,可从人的生理样品中进行鉴定与CMV感染者接触过的人表示已通过)。

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