The bacterium belonging to the Enterobacteriaceae family, and method for the production of L-cysteine, L-cystine, a derivative thereof, or a mixture thereof

摘要

The bacterium belonging to the Enterobacteriaceae family, and method for the production of L-cysteine, L-cystine, a derivative thereof, or a mixture of the same. A new technique to improve the ability of the production of L - cysteine of a bacterium is developed. So, are disclosed: a bacterium producing L - cysteine; and a process for the production of a compound such as L-cysteine by using the bacterium.L-cysteine, L-cystine, or a derivative thereof can be produced by culture of a bacterium that is able to produce L - cysteine, belonging to the Enterobacteriaceae family and has been modified so that the activity of a protein encoded by a gene YCI w (for example, a protein. As mentioned in Item (a) or (b)) is reduced in a culture medium.And collecting any of the compounds or a mixture of the culture medium. (a) a protein which has the amino acid sequence represented in SEQ ID No: 2.(b) a protein which has the amino acid sequence produced by substitution, deletion, insertion or addition of one or several amino acid residues in the amino acid sequence represented by SEQ ID No: 2, and which has a characteristic in which the ability of property Production of L - cysteine of the bacteria increases when the activity of the protein is decreased by the bacteria.