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Compound, process for preparing a compound, use of a compound, method for treating a disease or condition, pharmaceutical composition, process for preparing a pharmaceutical composition, product, and kit.

机译:化合物,化合物的制备方法,化合物的用途,治疗疾病或病症的方法,药物组合物,药物组合物的制备方法,产品和试剂盒。

摘要

Compounds of general formula (I) wherein W is chloro or fluoro; R1 is phenyl optionally substituted with one or more substituents selected from halo, -CN, -C1-C6 alkyl, -SOR3, -SO2R3, -SO2N(R2)2, -N(R2)2, -NR2C(O)R3, -CO2R2, -CONR2R3, -NO2, -OR2, -SR2, -O(CH2)pOR2, and -O(CH2)p-O-(CH2)qOR2 wherein each R2 is independently hydrogen, -C1-C6 alkyl, -C3-C8 cycloalkyl, aryl or heteroaryl; each R3 is independently, -C1-C6 alkyl, -C3-C8 cycloalkyl, aryl or heteroaryl; p and q are each independently an integer from 1 to 3; and their pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs are useful in orally administrable compositions for the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis.
机译:通式(I)的化合物,其中W是氯或氟; R1是任选被一个或多个选自卤素,-CN,-C1-C6烷基,-SOR3,-SO2R3,-SO2N(R2)2,-N(R2)2,-NR2C(O)R3, -CO2R2,-CONR2R3,-NO2,-OR2,-SR2,-O(CH2)pOR2和-O(CH2)pO-(CH2)qOR2,其中每个R2独立为氢,-C1-C6烷基,-C3- C8环烷基,芳基或杂芳基;每个R 3独立地为-C 1 -C 6烷基,-C 3 -C 8环烷基,芳基或杂芳基; p和q分别独立地是1至3的整数;及其药学上可接受的盐,水合物,溶剂化物,复合物或前药可用于口服组合物,用于治疗变应性疾病,例如哮喘,变应性鼻炎和特应性皮炎。

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