Pharmaceutical composition, tablet, and methods of treating a patient suffering from hepatitis c, reducing one or more of the side effects associated with nitazoxanide or tizoxanide treatment in a patient, increasing the bioavailability of nitazoxinide or its analog in a patient. , and to prolong the absorption of nitazoxanide or an analogue thereof in a patient

摘要

Solid dosage formulations of nitazoxanide or a nitazoxanide analogue are provided that comprise a controlled release portion and an immediate release portion. The pharmaceutical composition is typically in the form of a bilayer solid oral dosage form comprising (a) a first layer comprising a first quantity of nitazoxanide or analogue thereof in a controlled release formulation; and (b) a second layer comprising a second quantity of nitazoxanide or analogue thereof in an immediate release formulation. Method of using the formulations in the treatment of hepatitis C are also provided.