Monesin-containing pharmaceutical composition for treating diseases associated with Wnt deregulated signal path

摘要

ufeffu0159eu0161enu00ed relates to new biological activities of monensin, an antibiotic isolated from streptomyces cinnamonensis. monensin has been identified as a potent inhibitor of canonical wnt signal paths and it has demonstrated activity in several in vitro and in vivo tests.the invention applies in particular to the pharmaceutical preparation containing monensin or its pharmaceutically acceptable salt, for use in the treatment of diseases associated with deregulovanou runway wnt signal, especially in the treatment of diseases such as familial adenomatous polyp of colon -, colon cancer, rectal cancer and colorectal cancer.