SUSTAINABLE COMPOSITIONS WITH CONTROLLED SHIPPING

摘要

The present invention relates to compositions forming a non-liquid crystalline mixture with a low viscosity: a) from 25 to 55 wt.% At least one diacylglycerol and / or at least one tocopherol; b) from 25 to 55% by weight of at least one phospholipid component containing phospholipids, which have: i) polar end groups containing more than 50% phosphatidylethanolamine, and ii) two acyl chains, each of which independently has from 16 to 20 carbon atoms, characterized in that at least one acyl chain has at least one unsaturated bond in the carbon chain and no more than four unsaturated bonds in two carbon chains are present; c) from 5 to 25 wt.% at least one biocompatible, oxygen-containing, low viscosity organic solvent; characterized in that from 0.1 to 10 wt.% of at least one peptide active agent containing at least one somatostatin receptor agonist is dissolved or dispersed in a low viscosity mixture; and also characterized in that the candidate substance forms or is capable of forming at least one non-lamellar liquid crystal phase structure upon contact with an aqueous liquid. The invention also relates to processing methods, comprising administering a similar composition, and a pre-filled administration device and kits containing the compositions.