The present Invention relates in general to a fusion protein that is expressed in a cell can convert a negative Signal into a positive signal in the cell.The fusion protein is a protein quimu00c9rica characterized in that it comprises at least two Protein Domains, where a domain is the first polipu00c9ptido is associated with a negative signal and the second domain is a polipu00c9ptido is associated with a positive Signal.In this way, The Invention includes receiving Change signals that are able to change negative to positive signals for maximizing an immune response
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