Receptors co STIMULATORS of Change

摘要

Refers to a fusion protein comprising a First Domain, which is a polypeptide that is selected from the group consisting of CTLA4, pd-1 and BTLa, which is associated with a negative Signal; and a Second Domain, which is a polypeptide that is selected from the group consisting of CD28, ICOS, Q EU is associated with a positive Signal.The fusion protein also includes a transmembrane domain. In this way, The Invention includes receiving Change signals that are able to change negative to positive signals for enhancement of an immune response.