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Quantum dot ingrained and dual motif tethered artificial virus like structure for gene delivery

机译:量子点根深蒂固和双基元拴系人工病毒样结构,用于基因传递

摘要

Embodiments of the present invention report invention is related to an artificial virus like structure in the size range of 10-1000 nm for delivering gene. Quantum dot is ingrained in the artificial virus like structure which is dual motif tethered. The structure consists of a central core of citrate stabilized zinc oxide quantum dots capped with polyethyleneimine. To the core a covering of folic acid conjugated albumin and DNA(gene)conjugated to cell penetrating peptide is given to form the artificial virus like structure.
机译:本发明报告的实施方案涉及一种在10-1000nm的大小范围内用于递送基因的人造病毒样结构。量子点根植于人造病毒样结构中,该结构被双基元束缚。该结构由柠檬酸稳定的氧化锌量子点的中心核组成,并用聚乙烯亚胺覆盖。核心覆盖了叶酸结合的白蛋白和与细胞穿透肽结合的DNA(基因)的覆盖物,以形成人造病毒样结构。

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