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CaMKII, IP3R, CALCINEURIN, P38 AND MK2/3 INHIBITORS TO TREAT METABOLIC DISTURBANCES OF OBESITY.
CaMKII, IP3R, CALCINEURIN, P38 AND MK2/3 INHIBITORS TO TREAT METABOLIC DISTURBANCES OF OBESITY.
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机译:CaMKII,IP3R,钙蛋白,P38和MK2 / 3抑制剂可治疗肥胖的代谢紊乱。
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摘要
The present invention relates to methods of treating or preventing a metabolic disorder in a subject, methods of treating or preventing coronorary artery disease in a subject with a metabolic disorder, as well as methods of reducing hepatic glucose production in a subject. Such methods include, but are not limited to, the administration to the subject of inhibitors of CaMKII, IP3Rs, calcineurin, p38, MK2/3, or any combination thereof. The invention also provides methods of identifying a compound that inhibits the activity of CaMKII, IP3Rs, calcineurin, p38, or MK2/3, or reduces the activity and/or activation of CaMKII, IP3Rs, calcineurin, p38, or MK2/3.
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