STAPHYLOCOCCUS AUREUS SDRE CNAB DOMAIN AND ITS USE FOR VACCINATION.

摘要

The S.aureus Ser-Asp rich fibrinogen/bone sialoprotein-binding protein contains three CnaB domains, and that the third of these provides significant protection against S.aureus infection. Thus a useful S.aureus vaccine can include a SdrE CnaB domain. Furthermore, the SdrE protein has been shown to be relatively resistant to trypsin digestion, which could be connected to the observation that SdrE contains an isopeptide bond within the third CnaB domain.