A new polymorphous crystal form, 5 - (2 - 6 - (2,2-di-di-phenyl) hexamethylamine} - 1 - (R) - hydroxy) 8-hydroxyquinol-2 (1H) - ona, siminabadicia as a promoter of adrenergic receptor beta2

摘要

REFERED TO A CRYSTALLINE POLYMORPH OF 5- (2 - {[6- (2,2-DIFLUORO-2-PHENYLETHOXY) HEXYL] AMINO} -1 (R) -HYDROXYETHYL) -8-HYDROXYQUINOLIN-2 (1H) -ONE HEMINAPADISYLATE WHAT IS A HYDRATE POLYMORPH OR A BETA-TYPE POLYMORPH THAT IS OBTAINED BY DRYING SUCH A HYDRATE POLYMORPH, WHERE: a) THE X-RAY DIFFACTION POWDER DIAGRAM (XRPD) WITH PEAKS AT 13.3,16 1 Y 19 2 GRADOS 2 THETA (2B 2F- 0 1 GRADOS 2 THETA) Y 2FO UN DIAGRAMA DE CALORIMETRIA DIFERENCIAL DE BARRIDO (DSC) QUE MUESTRA UNA PRIMERA ENDOTERMA EN EL INTERVALO 75 C - 120 CY UNA SEGUNDA ENDOTERMA CON COMIENZO A 190 2 THETA (+/- 0.1 DEGREE 2 THETA) AND / OR A DIFFERENTIAL SWEEPING CALORIMETRY DIAGRAM (DSC) THAT PRESENTS AN ENDOTHERM WITH A START AT 190�C (+/- 1�C). IT IS ALSO REFERRED TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE USEFUL IN THE TREATMENT OF RESPIRATORY DISEASES ASSOCIATED WITH THE ACTIVITY OF THE BETA2 ADRENERGIC RECEPTOR